実験的ハムスター舌癌組織における神経線維の動態：抗ＮＦＰ，Ｓ‐１００蛋白抗体を用いた免疫組織化学的研究

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  • Responses of neural elements in the experimentally induced carcinoma of the hamster tongue: An immunohistochemical study using antibodies to neurofilament protein(NFP) and glia-specific S-100 protein.
  • An immunohistochemical study using antibodies to neurofilament protein (NFP) and glia-specific S-100 protein
  • 抗NFP, S-100蛋白抗体を用いた免疫組織化学的研究

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Innervation of carcinomas induced by application of 9, 10-dimethy1-1, 2-benzanthracene (DMBA) was investigated in the hamster tongue by using immunohistochemistry concerning neurofilament protein (NFP) and glia specific S-100 protein.<BR>The tumor induced by application of DMBA was a well-differentiated squamous cell carcinoma having cord-like invasion of the underlying fibrcus tissue and muscle layer.<BR>The characteristic feature of the innervation was the extreme scarcity of NFP-and S-100 pro tein-immunopositive neural elements recognized in the stroma and around blood vessels of the carcinomas.<BR>A few NFP-positive neural elements which were observed in the carcinoma invading zone were very fine and also found not to bear any relation to blood vesseles nor tumor nests.<BR>Unlike calcitonin gene-related peptide-positive nerves, a dense distribution of S-100 protein-positive neural elements characteristic of arterioles in the surrounding muscle layer was also not seen around arterioles abundant in the carcinoma invading zone.<BR>The results indicate a high pain threshold and the absence of autoregulatory mechanism in the blood vessels of the carcinoma tissue.

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