書誌事項
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- A case of methotrexate-associated lymphoproliferative disorder in the lower gingiva of a patient with rheumatoid arthritis that completely resolved after drug withdrawal
- カンセツ リウマチ カンジャ ノ カガク シニク ニ ハッショウ シタ メトトレキサート カンレン リンパ ゾウショクセイ シッカン ガ キュウヤク ニ ヨリ カンゼンカンホグシタ 1レイ
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The development of methotrexate (MTX)-associated lymphoproliferative disorder (MTX-LPD) in the oral cavity is rare, despite numerous recent reports on the treatment of rheumatoid arthritis (RA) with MTX. An 84-year-old woman with RA, who was receiving MTX therapy since November 2008, presented to our hospital in April 2010. She complained of pain, and a nodule, with deep ulceration and induration, was seen extending from the right lower gingiva to the buccal mucosa. Histopathological examination of a biopsy specimen showed a diffuse proliferation of mostly large atypical lymphocytes. The tumor cells were positive for CD20, CD79a, MUM1, and LMP1, accompanied by EBER-ISH positive reaction. The condition was diagnosed as Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma, which indicated MTX-LPD. MTX was discontinued. The tumor disappeared after 2 months. Within 8 months, the bone sequestrum spontaneously separated, and the affected area was covered with normal mucosa. Examination after 2 years 4 months did not show any evidence of recurrence.
収録刊行物
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- 日本口腔外科学会雑誌
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日本口腔外科学会雑誌 59 (5), 341-345, 2013
社団法人 日本口腔外科学会
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詳細情報 詳細情報について
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- CRID
- 1390001206530798848
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- NII論文ID
- 130004714392
- 40019694648
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- NII書誌ID
- AN00189163
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- ISSN
- 21861579
- 00215163
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- NDL書誌ID
- 024677980
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可