Level V 領域へ転移をきたした口腔扁平上皮癌の臨床病理組織学的検討

  • 武富 孝治
    久留米大学医学部歯科口腔医療センター
  • 中村 謙
    久留米大学医学部歯科口腔医療センター
  • 中村 守厳
    久留米大学医学部歯科口腔医療センター
  • 古賀 真
    久留米大学医学部歯科口腔医療センター
  • 岩本 修
    久留米大学医学部歯科口腔医療センター
  • 楠川 仁悟
    久留米大学医学部歯科口腔医療センター

書誌事項

タイトル別名
  • Clinicopathological investigation of oral squamous cell carcinoma resulting in metastasis to the Level V region
  • Level Ⅴ リョウイキ エ テンイ オ キタシタ コウコウ ヘンペイ ジョウヒガン ノ リンショウ ビョウリ ソシキガクテキ ケントウ

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Oral squamous cell carcinoma (OSCC) often metastasizes to the cervical lymph nodes, but Level V metastasis is infrequent, and the prognosis of such cases is extremely poor. We describe the clinicopathological features of Level V metastasis in patients with OSCC.<br>Four (1.9%) of 212 patients who underwent radical or modified radical neck dissection had histopathologically confirmed Level V metastasis. The primary site was the tongue in 1 patient, the lower gingiva in 2 patients, and the oral floor in 1 patient. Level V metastasis was associated with the mode of invasion, but not with T stage. In the patients with Level V metastasis, the mean total number of involved nodes on the affected side was 18.8, and the mean rate of conversion to positive status of the cervical lymph nodes was 49%. As for metastatic features, all patients showed metastasis to lymph nodes in the Level II region. The treatment outcome of Level V metastasis was poor, and all patients died of disease with a mean survival time of 9.3 months after neck dissection. In conclusion, although the frequency of Level V metastasis in oral squamous cell carcinoma was low, the prognosis was extremely poor. Furthermore, lymph-node metastases and extracapsular invasion in other regions appeared to be associated with Level V metastasis.

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