A case of drug-induced interstitial pneumonia possibly caused by S-1 treatment as postoperative adjuvant chemotherapy
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- KONDOU Eiji
- Department of Oral and Maxillofacial Surgery, Asahikawa Medical University
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- TAKEKAWA Masanori
- Department of Oral and Maxillofacial Surgery, Asahikawa Medical University
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- UTSUGI Chizuru
- Department of Oral and Maxillofacial Surgery, Asahikawa Medical University
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- YOSHIDA Masatsugu
- Department of Oral and Maxillofacial Surgery, Asahikawa Medical University
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- SHIBAYAMA Naohiro
- Department of Oral and Maxillofacial Surgery, Asahikawa Medical University
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- MATSUDA Mitsuyoshi
- Department of Oral and Maxillofacial Surgery, Asahikawa Medical University
Bibliographic Information
- Other Title
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- 術後補助化学療法に使用したS-1が原因と思われる薬剤性間質性肺炎の1例
- ジュツゴ ホジョ カガク リョウホウ ニ シヨウ シタ S-1 ガ ゲンイン ト オモワレル ヤクザイセイ カンシツセイ ハイエン ノ 1レイ
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Abstract
S-1 chemotherapy is widely used to treat head and neck cancer. Reports of interstitial pneumonia as a side effect of S-1 chemotherapy are very rare.<br>We report a case of interstitial pneumonia possibly caused by S-1 treatment as postoperative adjuvant chemotherapy.<br>We gave S-1 as postoperative adjuvant chemotherapy for mandibular gingival carcinoma in a 80-year-old woman. She had a fever 53 days after starting S-1 chemotherapy. The X-ray films and computed tomography (CT) showed reticular shadows in both lung fields, and the patient was given a diagnosis of interstitial pneumonia. The results of a drug-induced lymphocyte stimulation test were positive against S-1. The total dose of S-1 until the onset of symptoms was 3360 mg. We immediately started steroid therapy and withdrew S-1 chemotherapy, and then the symptoms remarkably improved, as did the abnormal findings on CT.<br>In conclusion, when a patient has a high fever and dyspnea during S-1 therapy, drug-induced interstitial pneumonia should be included in the differential diagnosis.
Journal
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- Japanese Journal of Oral and Maxillofacial Surgery
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Japanese Journal of Oral and Maxillofacial Surgery 60 (6), 342-347, 2014
Japanese Society of Oral and Maxillofacial Surgeons
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Details 詳細情報について
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- CRID
- 1390001206531170816
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- NII Article ID
- 130005083473
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- NII Book ID
- AN00189163
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- ISSN
- 21861579
- 00215163
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- NDL BIB ID
- 025625088
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- Text Lang
- ja
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed