A case of myxofibrosarcoma of the maxilla

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  • TORATANI Shigeaki
    Clinic of Oral and Maxillofacial Surgery, Hiroshima University Hospital
  • SAKAMOTO Akihiko
    Department of Molecular Oral Medicine and Maxillofacial Surgery, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University
  • OCHI Yasushi
    Department of Molecular Oral Medicine and Maxillofacial Surgery, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University
  • MIYAUCHI Mutsumi
    Department of Oral and Maxillofacial Pathobiology, Basic Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University
  • OGAWA Ikuko
    Center of Oral and Clinical Examination, Hiroshima University Hospital
  • OKAMOTO Tetsuji
    Clinic of Oral and Maxillofacial Surgery, Hiroshima University Hospital Department of Molecular Oral Medicine and Maxillofacial Surgery, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University

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Other Title
  • 上顎に発生した粘液線維肉腫の1例
  • ジョウガク ニ ハッセイ シタ ネンエキ センイ ニクシュ ノ 1レイ

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Abstract

Myxofibrosarcoma （MFS）, known previously as myxoid variant of malignant fibrous histiocytoma （myxoid MFH）, was reclassified to the category of fibroblastic/myofibroblastic tumors in 2002. MFS is defined as a malignant fibroblastic lesion with a variably myxoid stroma, pleomorphism, and a distinctively curvilinear vascular pattern. This lesion is one of the common soft tissue sarcomas, usually arising in the subcutaneous tissue of the limbs in elderly patients, but very rarely occurring in the head and neck region.<br>We report a case of MFS in the maxilla. A 39-year-old man visited our hospital because of an asymptomatic mass arising in the left side of the maxilla. Although an incisional biopsy specimen was initially diagnosed as odontogenic myxoma, histopathological and immunohistochemical analyses of the resected specimen finally suggested that the lesion was a MFS/myxoid MFH. There has been no evidence of local recurrence or metastasis as of 5 years after surgery.

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