腎切除後26年目に下顎骨へ転移したと考えられた腎細胞癌の1例

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  • A possible case of metastatic renal cell carcinoma to the mandible 26 years after nephrectomy
  • 腎切除後26年目に下顎骨へ転移しかと考えられた腎細胞癌の1例
  • ジンセツジョ ゴ 26ネンメ ニ カガクコツ エ テンイ シカト カンガエラレタ ジンサイボウガン ノ 1レイ

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Renal cell carcinoma (RCC) is infamous for unpredictable metastasis. This report describes a possible case of metastatic RCC to the mandible 26 years after nephrectomy. A 71-year-old woman was referred to our hospital because of hypoesthesia of the right submental region and a granulomatous mass arising in the right mandibular mucosa. The patient had undergone a right nephrectomy for clear cell carcinoma 26 years previously. Biopsy of the oral lesion revealed clear cell carcinoma, but whether the tumor was of oral origin or a metastasis could not be confirmed histopathologically. Furthermore, no other tumor mass was identified on evaluation of the entire body by FDG-PET scanning. The patient underwent a segmental mandibulectomy, radical neck dissection, and radiotherapy with a total dose of 60 Gy. Six months later, computed tomography revealed masses in the left kidney, mediastinum, retroperitoneum, pancreas, and the right primary nephrectomy region which were diagnosed as metastases from RCC. Finally, the mandibular lesion was considered to be a metastatic renal cell carcinoma. The patient received interferon, but died of the growing metastatic tumor.

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