書誌事項
- タイトル別名
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- PLGA artificial nerve conduits with dental pulp cells promote facial nerve regeneration
- シズイ サイボウ オ クミコンダ PLGA シンケイ ユウドウカン ワ ガンメン シンケイ サイセイ オ ソクシン スル
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説明
A number of recent studies have shown the effectiveness of tubulation, using neural progenitor cells or Schwann cells, for promoting nerve regeneration. However, the use of neural cells from other neural donor tissues can cause potentially serious clinical complications. Therefore, we focused on dental pulp as a new cell source for use in such artificial conditions. Previously, we showed that silicone tubes filled with dental pulp cells (DPCs) promoted facial nerve regeneration in rats. However, the use of silicone tubes requires a secondary removal operation because they may give rise to chronic inflammation and pain. Therefore, to avoid this procedure, a new artificial device was prepared from a degradable Copoly-lactide/glycolide (PLGA) tube containing DPCs, and its effectiveness for repairing gaps in the facial nerves of rats was investigated. A PLGA tube containing rat DPCs embedded in collagen gel was transplanted into a gap in a rat facial nerve. Five days after transplantation, the facial nerves connected by the PLGA tubes containing DPCs were repaired more quickly than the control nerves. The PLGA tubes were resorbed in vivo, and nerve regeneration was observed 2 months after transplantation. Immunostaining showed that Tuj1-positive axons were present in the regenerated nerves 2 months after transplantation, and osmium-toluidine blue staining showed no mineralization of the regenerated nerves in tubes containing myelinated fibers after 9 weeks. PLGA tubes filled with DPCs promoted nerve regeneration and were readily resorbed in vivo.
収録刊行物
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- 日本口腔外科学会雑誌
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日本口腔外科学会雑誌 59 (6), 404-411, 2013
社団法人 日本口腔外科学会
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詳細情報 詳細情報について
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- CRID
- 1390001206531267584
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- NII論文ID
- 40019725601
- 130004707962
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- NII書誌ID
- AN00189163
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- ISSN
- 21861579
- 00215163
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- NDL書誌ID
- 024731739
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可
