A case of idiopathic salivary hyperamylasemia

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  • NAGASAKI Atsuhiro
    Department of Oral and Maxillofacial Surgery, Kochi Medical　School, Kochi University
  • SENTOU Shinya
    Department of Oral and Maxillofacial Surgery, Kochi Medical　School, Kochi University
  • SASABE Eri
    Department of Oral and Maxillofacial Surgery, Kochi Medical　School, Kochi University
  • KITAMURA Naoya
    Department of Oral and Maxillofacial Surgery, Kochi Medical　School, Kochi University
  • YAMADA Tomohiro
    Department of Oral and Maxillofacial Surgery, Kochi Medical　School, Kochi University
  • YAMAMOTO Tetsuya
    Department of Oral and Maxillofacial Surgery, Kochi Medical　School, Kochi University

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Other Title
  • 特発性唾液腺型高アミラーゼ血症の1例
  • トクハツセイ ダエキセンガタ コウアミラーゼ ケツショウ ノ 1レイ

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Abstract

The elevation of serum amylase is generally associated with diseases of the pancreas or salivary glands. However, hyperamylasemia has also been noted to occur in a variety of conditions, such as amylaseproducing cancers, chronic viral liver disease, macroamylase, and after various surgical procedures. We describe a man in his fifties who was given a diagnosis of idiopathic salivary hyperamylasemia. He was referred to our clinic because of hyperamylasemia lasting over a 2-year-period, during which the patient remained asymptomatic. Blood examination at presentation revealed pancreatic and salivary amylase levels of 47 U/L and 626 U/L, respectively. No abnormal findings except for a kidney stone and renal atrophy were detected on further examinations, including abdominal ultrasonography, magnetic resonance cholangiopancreatography, magnetic resonance imaging of the salivary glands, and positron emission tomography-computed tomography. Furthermore, macroamylase was not detected on electrophoresis of serum amylase. On the basis of these results, idiopathic salivary hyperamylasemia was diagnosed. One and a half years later, serum levels of salivary amylase are still high.

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