Biosynthetic Study on THCA, the Psychoactive Component of Marijuana

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  • 大麻幻覚成分ＴＨＣＡの生合成研究
  • タイマ ゲンカク セイブン THCA ノ セイゴウセイ ケンキュウ

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Description

Cannabis sativa produces novel secondary metabolites called cannabinoids. Among them, Δ1-tetrahydrocannabinol (THC), the psychoactive component of this plant, has attracted a great deal of attention, because this cannabinoid is shown to exert a variety of therapeutic activities such as the relief of nausea caused by cancer chemotherapy. To reveal the mechanism of THC formation in Cannabis sativa, we attempted biosynthetic studies. Consequently, we established that Δ1-tetrahydrocannabinolic acid (THCA), the precursor of THC, is derived from cannabigerolic acid and that this reaction is catalyzed by the novel oxidocyclase, THCA synthase. Here, we show the biochemical and structural properties of THCA synthase.<br>

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 45 (4), 178-184, 2005

    The Biophysical Society of Japan General Incorporated Association

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