Structure and function of Ca2+-ATPase of sarcoplasmic reticulum.

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Other Title
  • 筋小胞体カルシウムＡＴＰａｓｅの構造と機能
  • キン ショウホウタイ カルシウム ATPase ノ コウゾウ ト キノウ

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Description

Sarcoplasmic reticulum Ca2+-ATPase is an integral membrane protein of Mr 110k and pumps Ca2+ against a large concentration gradient during relaxation of muscle. It is a member of Ptype ion pumps that include Na+, K+-ATPase and H+, K+-ATPase. Elaborated predictions of the secondary structure, assuming 10 transmembrane helices, have been proposed and a large body of experimental evidence seems to support this model. In particular, critical amino-acid residues implicated in the active transport have been identified by site-directed mutagenesis. Its unique three-dimensional structure has been revealed by cryo-electron microscopy. We now have some real structural basis to discuss about the active transport by P-type ion pumps.

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 37 (1), 310-314, 1997

    The Biophysical Society of Japan General Incorporated Association

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