Toxicity of daily concurrent preoperative chemoradiotherapy with docetaxel and cisplatin delivered by superselective intra-arterial infusion via the superficial temporal artery for oral cancer

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  • NAGAMINE Kenjiro
    Division of Oral and Maxillofacial Surgery, Fukuroi Municipal Hospital Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
  • YAMAMOTO Noriyuki
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
  • MITSUDO Kenji
    Department of Oral and Maxillofacial Surgery, Yokohama City Graduate School of Medicine
  • NISHIGUCHI Hiroaki
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
  • FUKUI Takafumi
    Department of Oral and Maxillofacial Surgery, Yokohama City Graduate School of Medicine
  • SHIGETOMI Toshio
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
  • HATANAKA Takashi
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine Oral and Maxillofacial Surgery, Nakatsugawa Municipal General Hospital
  • BOO Jae Seong
    Division of Oral and Maxillofacial Surgery, Fukuroi Municipal Hospital Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
  • TOHNAI Iwai
    Department of Oral and Maxillofacial Surgery, Yokohama City Graduate School of Medicine
  • UEDA Minoru
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine

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Other Title
  • 口腔癌に対するｄｏｃｅｔａｘｅｌ，ｃｉｓｐｌａｔｉｎを用いた浅側頭動脈よりの超選択的動注化学療法と放射線療法との術前連日同時併用療法の有害事象に関する検討
  • コウクウ ガン ニ タイスル docetaxel cisplatin オ モチイタ センソクトウ ドウミャク ヨリ ノ チョウセンタクテキ ドウチュウ カガク リョウホウ ト ホウシャセン リョウホウ トノ ジュツゼン レンジツ ドウジ ヘイヨウ リョウホウ ノ ユウガイ ジショウ ニ カンスル ケントウ

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Abstract

We have performed daily concurrent preoperative treatment combined with superselective intra-arterialinfusion chemoradiotherapy via the superficial temporal artery (HFT method) using docetaxel (DOC) and cisplatin (CDDP) in patients with oral cancer. Our purpose was to examine the toxicity of this treatment in order toassess its safety.<BR>The study group comprised patients with primary squamous cell carcinoma treated at our hospital. Thirty-ninepatients (28 men, 11 women) with stage II (4 patients), stage III (21 patients), or stage IV (14 patients) oralcancer were treated. Age ranged from 28 to 76 years (median age, 57 years). Primary cancer sites were thetongue (18 cases), mandible gingiva (8 cases), floor of the mouth (6 cases), maxillary gingiva (4 cases), andbuccal mucosa (3 cases).<BR>Radiotherapy (total dose: 40 Gy/4 weks) and HFT method using DOC (total dose: 60 mg/m2, 15mg/m2/week) and CDDP (total dose: 100mg/m2, 5mg/m2/day) were concurrently performed daily, followed bysurgery. Surgery for cancer was performed 4 weeks after preoperative combined therapy.<BR>Toxicity was evaluated according to the common toxicity criteria of the Society of Clinical Oncology. Toxicity ofgrade 4 was hemopoietic dysfunction (1 case), and that of grade 3 was hemopoietic dysfunction (8 case) andstomatitis (11 case). There was no toxicity of grade 3 or higher with regard to liver function, kidney function, respiratorydysfunction, or nausea. The clinical response was CR in 30 cases (76.9 %), PR in 8 (20.5%), and NC in1 (2.6%). The pathological response of the resected tumor was grade III or higher in 34 cases (87.1%). No patient was unable to continue preoperative-combined therapy because of toxicity. These findings suggest thatpreoperative combined therapy is a safe and useful treatment for oral cancer because of its low toxicity.

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