A case of polymorphous low-grade adenocarcinoma of the retromolar region

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  • KOJIMA Taku
    Division of Reconstructive Surgery for Oral and Maxillofacial Region, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences
  • SHINGAKI Susumu
    Division of Reconstructive Surgery for Oral and Maxillofacial Region, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences
  • SAITO Chikara
    Division of Reconstructive Surgery for Oral and Maxillofacial Region, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences
  • HAYASHI Takafumi
    Division of Oral and Maxillofacial Radiology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences
  • CHENG Jun
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences
  • SAKU Takashi
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences

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Other Title
  • 臼後部に発生した多型低悪性度腺癌の1例
  • キュウ コウブ ニ ハッセイ シタ タケイ テイアクセイドセンガン ノ 1レイ

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Abstract

Polymorphous low-grade adenocarcinoma （PLGA） is a rare malignant salivary gland tumor arising most commonly in the palate. We report a case of PLGA in a 72-year-old woman. The patient had a protrusive tumor, measuring 18 × 18 mm, in the left retromolar region. Radiographically, it was located in the submucosa with smooth and shallow resorption of the mandibular bone cortex. A biopsy suggested a benign salivary gland tumor, although a definitive diagnosis was not obtained. The tumor was surgically removed under general anesthesia. It was easily removed from the surface of the mandibular bone. Histopathological examination of the surgical specimen showed a relatively well-demarcated solid epithelial tumor with focal lack of a fibrous capsule. Tumor cells showed a monotonously basaloid appearance characterized by various architectural patterns, including solid, tubular, trabecular, and cribriform ones. Immunohistochemically, the tumor cells were positive for keratin 7, vimentin, and S-100 protein, which indicated myoepithelial characteristics. It was finally diagnosed as PLGA. The postoperative course has been uneventful as of 2 years after surgery.

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