A case of osteonecrosis of the mandible caused by bisphosphonates

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  • KISHI Naoko
    The first Department of Oral and Maxillofacial Surgery, Osaka University, Graduate School of Dentistry
  • ADACHI Tadafumi
    The first Department of Oral and Maxillofacial Surgery, Osaka University, Graduate School of Dentistry
  • KOIZUMI Hidehiko
    The first Department of Oral and Maxillofacial Surgery, Osaka University, Graduate School of Dentistry
  • IIDA Seiji
    The first Department of Oral and Maxillofacial Surgery, Osaka University, Graduate School of Dentistry
  • KOGO Mikihiko
    The first Department of Oral and Maxillofacial Surgery, Osaka University, Graduate School of Dentistry

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  • ビスフォスフォネートにより発症した下顎骨壊死の１例
  • ショウレイ ホウコク ビスフォスフォネート ニ ヨリ ハッショウ シタ カガクコツ エシ ノ 1レイ

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Abstract

Bisphosphonates (BPs) are widely used for the management of hypercalcemia related to malignancy and bone metastases from breast cancer in Japan. We report a case of osteonecrosis of the jaw (ONJ) associated with a history of BPs therapy forthe management of bone metastases from breast cancer. A 69-year-old woman was referred to our department becaused of unhealed extraction sockets of the lower left premolar and first molar, which were removed at a dental clinic. CT scans of the mandible showed regions of mottled bone and sequestra, and a clinical diagnosis of ONJ was made. After conservative treatment with antibiotics and local minor curettage, the inflammatory symptoms almost completely disappeared. Dentists should be aware of this potentially serious complication in patients receiving long-term treatment with BPs.

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