Fluconazole concentrations in human serum and mixed saliva after administration of fosfluconazole
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- KOMIYA Masamichi
- Department of Oral Surgery, Nihon University School of Dentistry at Matsudo
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- ONO Makiko
- Department of Oral Surgery, Nihon University School of Dentistry at Matsudo
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- TANAKA Shigeo
- Department of Oral Surgery, Nihon University School of Dentistry at Matsudo
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- SHIBUTANI Jun
- Department of Oral Surgery, Nihon University School of Dentistry at Matsudo
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- ISHII Tatsuo
- Department of Oral Surgery, Nihon University School of Dentistry at Matsudo
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- AKIMOTO Yoshiaki
- Department of Oral Surgery, Nihon University School of Dentistry at Matsudo
Bibliographic Information
- Other Title
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- Fosfluconazole投与後のヒト血清および唾液中fluconazole濃度
- Fosfluconazole トウヨ ゴ ノ ヒト ケッセイ オヨビ ダエキ チュウ fluconazole ノウド
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Abstract
The concentrations of fluconazole (FLCZ) in serum and mixed saliva after a single intravenous bolus injection of fosfluconazole (504.5mg) were determined by the paper disc method. The samples of serum and mixed saliva were obtained 0.5, 1, 2, 4, 8, and 24 hours after administration. The peak concentrations of FLCZ in serum and mixed saliva occurred 4 hours after administration of fosfluconazole and were 9.45±1.53 and 9.51±2.16μg/ml, respectively. The ratio of the mean concentration ratio of FLCZ in mixed saliva to that in serum was 0.97±0.17. The highest ratio (1.06) was noted 8 hours after administration. There was a significant correlation between the concentration of fluconazole in serum and that in mixed saliva (r=0.8466, p<0.01). A direct relation between the serum and mixed saliva concentrations of FLCZ was thus obtained. The saliva concentration was similar to the serum concentration, indicating that the saliva concentration is a reliable variable for therapeutic drug monitoring (TDM).
Journal
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- Japanese Journal of Oral and Maxillofacial Surgery
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Japanese Journal of Oral and Maxillofacial Surgery 51 (4), 161-165, 2005
Japanese Society of Oral and Maxillofacial Surgeons
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Details 詳細情報について
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- CRID
- 1390001206532101376
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- NII Article ID
- 10019220840
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- NII Book ID
- AN00189163
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- ISSN
- 21861579
- 00215163
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- NDL BIB ID
- 7332079
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed