下唇に発生した柵状被包性神経腫の1例

DOI Web Site Web Site 参考文献12件
  • 伊藤 良平
    弘前大学大学院医学研究科医科学専攻歯科口腔外科学講座
  • 中川 祥
    弘前大学大学院医学研究科医科学専攻歯科口腔外科学講座
  • 成田 紀彦
    弘前大学大学院医学研究科医科学専攻歯科口腔外科学講座
  • 田村 好拡
    弘前大学大学院医学研究科医科学専攻歯科口腔外科学講座
  • 佐竹 杏奈
    弘前大学大学院医学研究科医科学専攻歯科口腔外科学講座
  • 小林 恒
    弘前大学大学院医学研究科医科学専攻歯科口腔外科学講座

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タイトル別名
  • A case of palisaded encapsulated neuroma of the lower lip
  • シタクチビル ニ ハッセイ シタ サクジョウ ヒホウセイ シンケイ シュ ノ 1レイ

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<p>Palisaded encapsulated neuroma (PEN) is a benign, distinctive variant of cutaneous neuroma that is composed of normal nerve tissue. It usually presents as a solitary, asymptomatic, normal-colored papule. PEN should be histologically distinguished from other neural neoplasms, including schwannoma, neurofibroma, and traumatic neuroma.</p><p>　We present a case of PEN of the lower lip in a 50-year-old woman who visited our department because of an asymptomatic mass on her lower lip. She had no history of trauma. We suspected a fibroma based on clinical findings and removed the mass with the patient under local anesthesia. Histological and immunohistochemical examinations revealed a well-circumscribed spindle-shaped tumor, S-100 protein-positive cells, and neurofilament-positive nerve axons arranged in fascicles. The capsule of the tumor was positive for epithelial membrane antigen. The pathological diagnosis of the specimen was PEN. No sign of recurrence was observed 20 months after surgery.</p><p>　Cases of oral PEN, although a relatively common mucocutaneous peripheral nerve sheath lesion, seem to be rarely documented. This suggests that PEN might be misdiagnosed as other types of neural neoplasms. Immunohistochemical staining should be actively conducted for differential diagnosis between PEN and other neural neoplasms.</p>

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