A case of multiple oral cancer with aplastic anemia

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  • TAKECHI Masaaki
    First Department of Oral and Maxillofacial Surgery, School of Dentistry, The University of Tokushima
  • KAMATA Nobuyuki
    First Department of Oral and Maxillofacial Surgery, School of Dentistry, The University of Tokushima
  • KUME Keiko
    First Department of Oral and Maxillofacial Surgery, School of Dentistry, The University of Tokushima
  • YUASA Tetsuya
    First Department of Oral and Maxillofacial Surgery, School of Dentistry, The University of Tokushima
  • TATEHARA Seiko
    First Department of Oral and Maxillofacial Surgery, School of Dentistry, The University of Tokushima
  • NAGAYAMA Masaru
    First Department of Oral and Maxillofacial Surgery, School of Dentistry, The University of Tokushima

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  • 再生不良性貧血患者にみられた異時性口腔多発癌の１例

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We report a case of multiple oral cancer with aplastic anemia.<BR>The patient was 25-year-old man who was referred to our department for treatment of a mass in the right side of the maxillary gingiva in July 2001. He was given a diagnosis of aplastic anemia at 7 years of age. The maximum amount of mouth opening was 15mm, and a mass with an ulcer was present in the right upper molar region. Computed tomographic examination showed a mass and bone defect in the right maxillary sinus. A biopsy was performed, and the histopathological diagnosis was squamous cell carcinoma. After radiation therapy (external irradiation with 60Co-γ rays), we conducted operation. Red cell and platelet transfusions as well as granulocyte colony-stimulating factor (G-CSF) administration were performed before operation because of decreased numbers of blood cells, and the patient underwent a pertial maxillectomy.<BR>In October 2002, a tumorous lesion appeared in the left side of the mandibular gingiva, and a biopsy revealed squamous cell carcinoma. After the platelet transfusion, resection of the tumor was performed. There has been no evidence of recurrence or metastasis for more than 1 year after surgery.

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