書誌事項
- タイトル別名
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- Fluctuation of the type I collagen cross-linked C-telopeptide value in urine after withdrawal of bisphosphonates
- ビスフォスフォネート セイザイキュウヤク ニ ヨル ニョウチュウ Iガタ コラーゲン カケハシ C-テロペプタイドチ ノ ヘンドウ ニ ツイテ
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説明
We previously reported that the measurement of type I collagen cross-linked C-telopeptide in urine （u-CTX） is useful for evaluating the risk of developing bisphosphonate （BP） -related osteonecrosis of the jaw （BRONJ）. In this study, we observed fluctuations of the u-CTX value after the withdrawal of BP.<br>The subjects were 84 patients who were using BP in whom the withdrawal of BP for 3 months was possible. The u-CTX value is expressed as the interquartile range （median ［25% point, 75% point］. The u-CTX value before withdrawal was 59.5 ［36.0, 99.8］ Cr value, and increased to 110.0 ［69.3, 161.5］ Cr value 3 months after withdrawal （p<0.001）. Although we previously presented the cutoff value （98 Cr value） of u-CTX as related to the risk of developing BRONJ, the u-CTX value in this study was lower than the 98 Cr value before withdrawal, and increased to a level higher than the 98 Cr value after withdrawal for 3 months in 35 （56.5%） of 62 patients in the oral administration group, as compared with only 1 （11%） of 9 patients in the injection administration group. Furthermore, this was noted in 19 （47%） of 40 patients in the steroid non-combined use group and only 6 （27%） of 22 patients in the combined use group. Forty-one patients with a u-CTX value of higher than 98 Cr did not develop BRONJ after an extraction. Of the 9 patients with a u-CTX value of less than 98 Cr, 3 developed BRONJ after an extraction.<br>These results suggest that improvement in the bone metabolic capacity, which was being suppressed by BP, can be detected by measuring the u-CTX value after the withdrawal of BP, and this value might be a useful index to judge the appropriate time for tooth extraction. However, it should be noted that the u-CTX values in patients who received BP injections or the combined use of steroids were low before withdrawal and did not readily increase even after withdrawal.
収録刊行物
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- 日本口腔外科学会雑誌
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日本口腔外科学会雑誌 60 (4), 177-185, 2014
社団法人 日本口腔外科学会
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詳細情報 詳細情報について
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- CRID
- 1390001206532563968
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- NII論文ID
- 130005072003
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- NII書誌ID
- AN00189163
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- ISSN
- 21861579
- 00215163
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- NDL書誌ID
- 025476043
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
