Computer simulations of metabolic pathways and a matabolic control theory.

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  • WADANO Akira
    Laboratory of Biochemistry, Department of Agricultural Chemistry. University of Osaka Prefecture

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  • 生体内代謝経路のコンピューターシミュレーション
  • セイタイナイ タイシャ ケイロ ノ コンピューター シミュレーション

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Abstract

Computer simulations of metabolic pathways should use a realistic models concerning parameters of enzyme kinetics, and cell dimensions. The enzyme parameters are well determined with a best fit method. And it had better that the models for the analyses of enzyme kinetics is selected on the basis of AIC. Computer simulation of metabolic pathways is a convenient tool for the elucidation of control coefficients. The control coefficient is more quantitative concept to represent a flux control than limiting step is.

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 33 (2), 99-104, 1993

    The Biophysical Society of Japan General Incorporated Association

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