Imaging and nano-manipulation of single motor molecules.

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Other Title
  • 生体におけるイメージング技術の発展　分子，細胞，組織の動態を可視化する　１分子イメージング，１分子ナノ操作　１分子モーターの運動と酵素反応を観る
  • 1 ブンシ イメージング 1 ブンシ ナノ ソウサ 1 ブンシ モーター ノ
  • -1分子モーターの運動と酵素反応を観る-

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Description

Single fluorescent dye molecules were visualized at video-rate in aqueous solution by using total internal reflection fluorescence microscopy. This approach enabled us to directly image single myosin molecules and detect individual ATP turnover reactions. This approach also can be used to directly image single fluorescently-labeled kinesin molecules moving on an axoneme. The methods can be extended to simultaneous measurements of the ATPase reaction and force/movement by single motor protein molecules. This should provide a clear answer to the fundamental problem of how mechanical reaction is coupled to ATPase reaction.

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 36 (1), 5-9, 1996

    The Biophysical Society of Japan General Incorporated Association

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