筋収縮の滑り説の現状と問題点について

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タイトル別名
  • Current status and problems in the sliding-filament theory of muscle contraction
  • キン シュウシュク ノ スベリセツ ノ ゲンジョウ ト モンダイテン ニ ツイ

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説明

Although almost thirty years have paased since the discovery that muscle contraction results from relative sliding of the myofilaments, the molecular mechanism of the crossbridge motion responsible for contraction still remains as a matter of speculation. In this article, the problems of the sliding filament models of Huxley (1957)and Huxley and Simmons(1971), which are central in the field of muscle research, are discussed in relation to the followillg six topics, i.e. (1) constancy of the myofilament lengths during contraction, (2) experimental evidence for and against the Huxley-Simmons contraction model, (3) experimental evidence against the myosin head rotation mechanism, (4) problems on the sarcomere length-force relation, (5) possible mechanism of the force enhancement after stretch and. (6) relation between the velocity of shortening and the number of attached cross-bridges.<BR>It is concluded that the above models are now far from being complete, and from the standpoint of muscle physiology, much more experimental work with physical and chemical techniques should be performed on the preparations in which the three-dimensional myofilament lattice structures are preserved.

収録刊行物

  • 生物物理

    生物物理 23 (5), 221-231, 1983

    一般社団法人 日本生物物理学会

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