下顎骨内に広範に進展した原発不明悪性黒色腫の1例

  • 本橋 征之
    朝日大学歯学部口腔病態医療学講座口腔外科学分野
  • 住友 伸一郎
    朝日大学歯学部口腔病態医療学講座口腔外科学分野
  • 村松 泰徳
    朝日大学歯学部口腔病態医療学講座口腔外科学分野
  • 田中 四郎
    朝日大学歯学部口腔病態医療学講座口腔外科学分野
  • 永山 元彦
    朝日大学歯学部口腔病態医療学講座口腔病理学分野
  • 式守 道夫
    朝日大学歯学部口腔病態医療学講座口腔外科学分野

書誌事項

タイトル別名
  • A case of malignant melanoma from an unknown primary site that extensively invaded the mandibular bone
  • カガクコツ ナイ ニ コウハン ニ シンテン シタ ゲンパツ フメイ アクセイ コクショク シュ ノ 1レイ

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抄録

To our knowledge, a case of primary oral malignant melanoma (MM) invading mainly the jaw has yet to be reported. We report a case of MM that spread widely in the mandibular medullary cavity with limited involvement of the mucosa. <BR>A 40-year-old woman visited our hospital because of mobility of the lower right second molar. Initial examination showed that the second molar floated, and the gingiva was pale purple-blue. An X-ray film showed a diffuse radiolucent area from the premolar to the ramus of the right mandible. The diagnosis of a biopsy specimen was MM, and no distant metastasis was detected on whole body examination. A wide tumor resection with radical neck dissection and immediate reconstruction were performed. Histopathological examination of the specimen revealed MM invading mainly the mandibular bone marrow; however, the primary site remained unknown. DAV-Feron therapy was given postoperatively. Three months later, left cervical lymph node metastasis was detected, and neck dissection was performed. Three years after the first visit, a metastatic lesion in the pleural space was excised by thoracosopic surgery. Ten courses of DAV-Feron therapy were completed, and the patient is now under observation.

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