A case of Kimura's disease (eosinophilic lymphfolliculoid granuloma) associated with nephrotic syndrome diagnosed because of cheek swelling

KANDA Taku, TORATANI Shigeaki, YAMASAKI Sachiko, ITOH Nanako, OGAWA Ikuko, OKAMOTO Tetsuji

doi:10.5794/jjoms.59.83

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頬部腫脹を契機に診断されたネフローゼ症候群を伴った木村病の1例
頰部腫脹を契機に診断されたネフローゼ症候群を伴った木村病の1例
ホオブシュチョウオケイキニシンダンサレタネフローゼショウコウグンオトモナッタキムラビョウノ 1レイ
A case of Kimura^|^apos;s disease (eosinophilic lymphfolliculoid granuloma) associated with nephrotic syndrome diagnosed because of cheek swelling

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Abstract

Kimura's disease is a rare benign chronic granulomatous lesion of soft tissue or lymph nodes of the head and neck region and is characterized by eosinophilia and an increased serum IgE level in peripheral blood. Kimura's disease is reported to be associated with renal disturbance, but the pathogenesis of this association remains obscure. We report a case of Kimura's disease associated with nephrotic syndrome.<BR>Two years before the first visit, the patient complained of a mass with painless swelling in the left cheek and on both sides of the neck. Remission and relapse of the mass occurred several times in association with the dose of steroids administered for nephrotic syndrome. Laboratory investigations revealed peripheral blood eosinophilia and an elevated serum IgE level. The mass in the cheek was surgically enucleated for esthetic purposes and definitive diagnosis. Histopathological examination indicated eosinophilic lymphfolliculoid granuloma; thus, Kimura's disease was finally diagnosed. The patient has received continuous pharmacotherapy with steroids and immunosuppressive drugs; the mass shrank on both sides of the neck, and good clinical status has been maintained.

Journal

Japanese Journal of Oral and Maxillofacial Surgery

Japanese Journal of Oral and Maxillofacial Surgery 59 (2), 83-87, 2013

Japanese Society of Oral and Maxillofacial Surgeons

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