ミオシンホスファターゼ阻害タンパク質ＣＰＩ‐１７の構造と機能

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タイトル別名
  • Structural Basis of a Myosin Phosphatase Inhibitory Protein, CPI-17
  • ミオシンホスファターゼ阻害タンパク質CPI-17の構造と機能
  • ミオシンホスファターゼ ソガイ タンパクシツ CPI 17 ノ コウゾウ ト キノウ

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説明

Cell motility, including smooth muscle contraction and cell migration, is regulated by reversible phosphorylation of myosin. Recent studies have shown that myosin phosphatase (MP), along with kinases, contributes dynamically to the regulation of myosin-II phosphorylation. An MP specific inhibitor named CPI-17, which is expressed in smooth muscle and neuronal cells, mediates receptor signaling leading to myosin-II phosphorylation. In this review, we discuss structure/function relationships of CPI-17 stemming from our recent NMR studies and computer modeling results. The combination of biophysical approaches with biochemical techniques has revealed the inhibitory mechanism of CPI-17.<br>

収録刊行物

  • 生物物理

    生物物理 45 (2), 72-77, 2005

    一般社団法人 日本生物物理学会

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