A case of remitting seronegative symmetrical synovitis with pitting edema (RS3PE) induced by UFT in a patient with metastatic foci of unknown origin

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  • ISHIKAWA Tohru
    Department of Oral and Maxillofacial Surgery, Ehime University School of Medicine
  • NAKASHIRO Koh-ichi
    Department of Oral and Maxillofacial Surgery, Ehime University School of Medicine
  • HINO Satoshi
    Department of Oral and Maxillofacial Surgery, Ehime University School of Medicine
  • SUMIDA Tomoki
    Department of Oral and Maxillofacial Surgery, Ehime University School of Medicine
  • SHINTANI Satoru
    Department of Oral and Maxillofacial Surgery, Ehime University School of Medicine
  • HAMAKAWA Hiroyuki
    Department of Oral and Maxillofacial Surgery, Ehime University School of Medicine

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Other Title
  • 原発不明頚部リンパ節転移巣を有する癌患者に認められたＵＦＴ誘発ｒｅｍｉｔｔｉｎｇ　ｓｅｒｏｎｅｇａｔｉｖｅ　ｓｙｍｍｅｔｒｉｃａｌ　ｓｙｎｏｖｉｔｉｓ　ｗｉｔｈ　ｐｉｔｔｉｎｇ　ｅｄｅｍａ（ＲＳ　３　ＰＥ）の１例
  • ショウレイ ホウコク ゲンパツ フメイ ケイブ リンパセツ テンイ ソウ オ ユウスル ガン カンジャ ニ ミトメラレタ UFT ユウハツ remitting seronegative symmetrical synovitis with pitting edema RS 3 PE ノ 1レイ

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We encountered a patient in whom remitting seronegative symmetrical synovitis with pitting edema (RS3PE) developed after treatment with UFT. A 64-year-old man who had cervical and lung metastases of unknown origin was treated with docetaxel hydrate, cisplatin, and 5-fluorouracil. Subsequently, the patient received UFT at a dose of 300 mg/day. Shortly after starting treatment with UFT, symmetrical pitting edema developed in the dorsum of the hands and feet. Since the results of immunological examination were consistently negative for rheumatoid factor, the patient was given a diagnosis of RS3PE. The symptoms of RS3PE markedly improved after the withdrawal of UFT and the start of steroid therapy. The findings suggested that UFT may be related to the development of RS3PE.

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