Feynman's Thermal Ratchet Mechanism on Kinesin Motors

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  • NISHIYAMA Masayoshi
    Department of Chemistry, Graduate School of Science, Kyoto University
  • HIGUCHI Hideo
    Department of Metallurgy, Graduate School of Engineering, Tohoku University

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  • キネシンの運動解析から見えてきた熱ラチェットメカニズム
  • キネシン ノ ウンドウ カイセキ カラ ミエテ キタ ネツ ラチェットメカニズム

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Description

Kinesin is an ATP-driven molecular motor that moves processively along a microtubule in a stepwise manner. The steps occur not only in the forward direction, but also in the backward. Here, we have studied the bidirectional stepping mechanism of kinesin motors. The stepping mechanism of the forward and backward movements was well characterized by Feynman's thermal ratchet model. The driving force of the stepwise movement is essentially Brownian motion, but it is biased in the forward direction by utilizing the free energy released from the hydrolysis of ATP.

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 44 (2), 75-80, 2004

    The Biophysical Society of Japan General Incorporated Association

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