Clinicopathological study of intravascular papillary endothelial hyperplasia in the oral cavity: Report of 10 cases with a review of the literature

HORII Shinya, KOBAYASHI Takanori, IIDA Akihiko, SAITO Chikara, HAYASHI Takafumi, SAKU Takashi, TAKAGI Ritsuo

doi:10.5794/jjoms.57.2

Intravascular papillary endothelial hyperplasia （IPEH） is a reactive lesion histopathologically characterized by papillary proliferation of endothelial cells in organizing thrombi formed in dilated blood vascular spaces.We studied the clinicopathological features of 10 cases of IPEH treated at the Niigata University Hospital during the last 12 years from 1998 through 2009 and reviewed the literature. The patients were 5 men and 5 women.Their age mean was 51.2 years （range, 21 to 72）. The lesions were most frequently located in the lower lip （5 cases）, followed by the tongue （2 cases）, and the buccal mucosa, gingivobuccal fold, and maxillary sinus （1 each）. The lesions were all covered by mulberry-colored mucosae, measuring 8.6 mm in average diameter （range, 3 to 12 mm）, while they were rather elastic on palpation and did not always fade on compression. Most ofthe clinical diagnoses were hemangioma （7 cases）, while the diagnosis of hemangioma was ruled out in 2 cases arising in the lower lip and tongue by ultrasonography, which revealed high blood flow inside the lesion. All cases were surgically removed in accordance with the procedure for hemangioma, without recurrence. Thus, the application of ultrasonographic examination before surgery was suggested to be useful for the differential diagnosis of IPEH from hemangioma.

Clinicopathological study of intravascular papillary endothelial hyperplasia in the oral cavity: Report of 10 cases with a review of the literature

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