じん近位尿細管細胞膜におけるイオン透過性　Ｉ　　ＫおよびＨＣＯ?S３?Tイオンの基底側膜電位形成における役割

佐藤 賢三

doi:10.2142/biophys.15.238

じん近位尿細管細胞膜におけるイオン透過性　Ｉ　　ＫおよびＨＣＯ?S３?Tイオンの基底側膜電位形成における役割

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佐藤賢三

マックスプランク生物物理研究所及びニューヨーク州立バッファロー大学

書誌事項

タイトル別名

The permeability of the peritubular cell membrance fork+, HCO3-, Na+ and cl- in the rat kidney proximal tubule
ジンキンイニョウサイカンサイボウマクニオケルイオントウカセイ
K及びHCO3イオンの基底側膜電位形成に於る役割

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説明

Using a semi-floating glass microelectrode, the permeability of the peritubular membrane for Na, K. HCO₃ and Cl was studied in the rat kidney proximal tubule in vivo. The magnitude of the change in membrane and transepithelial p.d. due to peritubular ionic replacement was analyzed by means of an equivalent circuit analysis. The results of the present study showed that the peritubular p.d. is composed mostly of the diffusion p.d. of K and HCO₃. The contribution of Na and Cl to the membrane current appears to be negligible. The transference number of the peritubular cell membrane was 0.57 for K, 0.42 for HCO₃ and less than 0.01 for Na.