細胞内ATPの分布とダイナミクス,その制御

書誌事項

タイトル別名
  • Distribution and Dynamics of Intracellular ATP Level, and their Regulation
  • サイボウ ナイ ATP ノ ブンプ ト ダイナミクス,ソノ セイギョ

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抄録

ATP is indispensable for all living organisms. Despite its importance, however, distribution and dynamics of ATP level inside living cells still remained unclear. We have developed FRET-based ATP biosensors, “ATeam” and “GO-ATeam”, which enabled us to visualize intracellular ATP level. Using these biosensors, we have successfully evaluated the effect of IF1 protein and Ca2+ on regulation of ATP level. Also, we found that replication of hepatitis C virus genome resulted in the declination of cytosolic ATP level of host cells and the formation of putative virus replication sites with high ATP levels.<br>

収録刊行物

  • 生物物理

    生物物理 53 (1), 020-023, 2013

    一般社団法人 日本生物物理学会

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