Molecular Dynamics of Photo-electrical Transducing Proteins, Channelrhodopsins

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  • YAWO Hiromu
    Tohoku University Graduate School of Life Sciences JST-CREST Tohoku University Basic and Translational Research Center for Global Brain Science
  • TANIMOTO Saki
    Tohoku University Graduate School of Life Sciences JST-CREST Tohoku University Basic and Translational Research Center for Global Brain Science
  • ISHIZUKA Toru
    Tohoku University Graduate School of Life Sciences JST-CREST
  • TAKAHASHI Tetsuo
    Faculty of Pharmaceutical Sciences, Toho University

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Other Title
  • 光電変換タンパク質チャネルロドプシンの動作メカニズム
  • コウデン ヘンカン タンパクシツ チャネルロドプシン ノ ドウサ メカニズム

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Abstract

Channelrhodopsins (ChRs), which were first identified from Chlamydomonas genome, are light-gated ion channels. Although ChRs are now widely applied for optogenetics in many biomedical fields such as neuroscience, the mechanisms are mostly unknown how the light absorption can gate the ion channel to be open. In this review, the photocurrent kinetics of ChRs is discussed in relation to the photocycle models. The glutamic acid residues uniquely present in B helix appear to regulate the flux of permeable cations. One of them, E97 would lie in the outer pore and interact with a cation to facilitate the dehydration.<br>

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 52 (5), 226-229, 2012

    The Biophysical Society of Japan General Incorporated Association

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