Molecular Basis of DNA Quality Control for Mammalian Nucleotide Excision Repair

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  • AKITA Masaki
    Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University
  • SUGASAWA Kaoru
    Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University

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Other Title
  • ヌクレオチド除去修復におけるDNA品質管理の分子基盤
  • ヌクレオチド ジョキョ シュウフク ニ オケル DNA ヒンシツ カンリ ノ ブンシ キバン

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Abstract

For organisms, a fundamental problem is how the huge genome can be searched appropriately for DNA damage in order to prevent genome instability and/or cell death. In mammalian nucleotide excision repair (NER), this process involves multiple protein factors containing the xeroderma pigmentosum gene products (UV-DDB, XPC, TFIIH), which sense different aspects of DNA structural abnormalities, respectively. Coordinated stepwise actions of these factors contribute to simultaneous achievement of versatility, efficiency and accuracy of the DNA quality control for NER.

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 55 (3), 137-141, 2015

    The Biophysical Society of Japan General Incorporated Association

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