Computational Approaches for Long Non-coding RNA Research

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  • IWAKIRI Junichi
    Graduate School of Frontier Sciences, University of Tokyo
  • HAMADA Michiaki
    Department of Electrical Engineering and Bioscience, Faculty of Science and Engineering, Waseda University

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Other Title
  • 長鎖ノンコーディングRNAのためのバイオインフォマティクス
  • チョウサ ノンコーディング RNA ノ タメ ノ バイオインフォマティクス

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Abstract

<p>Recent advances in high throughput sequencing technologies unveiled that large number of long non-coding RNAs (lncRNAs) are transcribed from human genome. Currently, these emerging transcripts are needed to be functionally classified and annotated. Here we review several bioinformatic approaches for analyzing the important characteristics of the lncRNAs toward discovering their functions: 1) tissue specificities of lncRNA expressions, 2) two types of macromolecular interactions (RNA-RNA and RNA-protein interactions), 3) secondary structures of lncRNAs.</p>

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 56 (4), 217-220, 2016

    The Biophysical Society of Japan General Incorporated Association

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