遺伝暗号リプログラミング技術

書誌事項

タイトル別名
  • Genetic Code Reprogramming
  • イデン アンゴウ リプログラミング ギジュツ

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説明

Genetic code reprogramming enables us to assign nonproteinogenic amino acids to codons in place of proteinogenic amino acids according to the genetic code, which allows us to express desired nonstandard peptides using an in vitro translation system. Here, we discuss FIT (Flexible In vitro Translation) system, which is a method that facilitates genetic code reprogramming by employing flexizymes. Furthermore, we also report a method called RaPID (Random non-standard Peptide Integrated Discovery) system, which is an integration of FIT system with an in-vitro mRNA display. RaPID system allows us to select peptides with high binding affinities from highly diverse nonstandard peptide libraries and is quickly becoming a valuable new tool for drug discovery.<br>

収録刊行物

  • 生物物理

    生物物理 52 (1), 004-009, 2012

    一般社団法人 日本生物物理学会

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