DNA Repair and Evolutionary Considerations

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  • KONDO Sohei
    Department of Fundamental Radiology, Faculty of Medicine, Osaka University

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Other Title
  • DNA修復と進化論的考察
  • DNA シュウフク ト シンカロンテキ コウサツ

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Description

Recent knowledge of DNA repair is reviewed in perspective with emphasis on Escherichia coli. Enzymatic phtoreactivation is the simplest and the most general among the three major DNA repair systems. Excision repair is also common from microorganisms to human and yet its molecular mechanism is not universal. Tolerance repair, i.e., post-replication repair, is effective for the widest variety of DNA damage and rather different between lower and higher forms. From these characteristics, it is proposed that DNA repair mechanisms evolved in the order of photoreactivation, excision repair and tolerance repair after the primary living systems were created by solar ultraviolet.

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 14 (3), 118-126, 1974

    The Biophysical Society of Japan General Incorporated Association

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