栄養回復期における肝脂質蓄積の栄養的制御に関する研究　Ｉ　　絶食または低栄養後における各種栄養素の肝脂質蓄積に及ぼす影響

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タイトル別名
  • Nutritional Regulation of the Accumulation of Hepatic Lipid at the Nutritional Repletion Period (Part 1)
  • エイヨウ カイフクキ ニ オケル カン シシツ チクセキ ノ エイヨウテキ セ
  • 絶食または低栄養後における各種栄養素の肝脂質蓄積に及ぼす影響

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For the purpose of clarifying the interrelationships of nutrition and the occurrence of fatty liver, the effects of various nutrients on liver lipid contents, especially cholesterol concentration have been studied in fasted-refed rats or in rats shifted from a mineral-free diet to a mineral repletion diet.<br>1) Total lipids and cholesterol contents of the liver were significantly increased in rats refed a diet containing sucrose as the sole carbohydrate source after a fast for 48 hours, but it seemed that there were no influences in rats refed the diet containing corn starch. These changes were the same in both sex.<br>2) In spite of the presence or absence of dietary fat, total liver lipids were more increased in the group refed the sucrose diet than in the group refed the starch diet. However, liver cholesterol levels of the animals refed the fat free diet were remarkably elevated than those placed on the diet containing fat regardless of the carbohydrate source.<br>3) As the influence of several refed diets depleted individual dietary components except carbohydrate, both a protein free diet and mineral free diet markedly suppressed the increment of liver total lipids and cholesterol induced by the dietary sucrose. A diet free from water soluble vitamins also depressed the accumulation of hepatic lipids.<br>4) A rapid increase of liver total lipids in the rats refed the mineral repletion diet for 3 days after 7 days feeding of the mineral depletion diet was observed when sucrose, but not starch was used as the sole carbohydrate source.

収録刊行物

  • 栄養学雑誌

    栄養学雑誌 35 (6), 275-281, 1977

    特定非営利活動法人 日本栄養改善学会

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