脂肪酸組成の異なる３種のリン脂質及びその関連油脂のラット血清コレステロール上昇抑制効果の比較

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  • Comparison of hypocholesterolemic effect among three phospholipids containing different fatty acid and the related oils in rats.
  • シボウサン ソセイ ノ コトナル 3シュ ノ リン シシツ オヨビ ソノ カン

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Effects of dietary soybean-, egg yolk- and krill-phospholipids, and soybean and sardine oil on serum and liver cholesterol concentrations were investigated using weanling rats fed a hypercholesterolemic diet for 2 weeks. Serum total cholesterol concentrations were significantly lower and the ratio of HDL-cholesterol to total cholesterol was higher in all the experimental groups than those of the control group (olive oil). Liver cholesterol and triglyceride concentrations decreased in all the experimental groups, especially in the phospholipid groups. The apparent excretory ratio of fecal to dietary cholesterol gradually elevated in every phospholipid group with the lapse of experimental period, where the values of the soybean- and egg yolk-phospholipid groups were higher than that of the krill-phospholipid group, and those of the soybean and sardine oil groups were kept at a low level throughout the experimental period. The contents of choloroform/methanol-soluble phosphorus in feces tended to elevate as the cholesterol excretion increased. These results indicate that the different mechanism in hypocholesterolemic effect exists between phospholipids and polyunsaturated fatty acids, and that the phospholipids containing a large amount of higher polyunsaturated fatty acids such as eicosapentaenoic acid probably prevent the hypocholesterolemic effect.

収録刊行物

  • 栄養学雑誌

    栄養学雑誌 48 (5), 213-220, 1990

    特定非営利活動法人 日本栄養改善学会

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