Effects of Spa Therapy Combined with Dietary Supplementation with n-3 Fatty Acids on Bronchial Asthma

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  • OKAMOTO Makoto
    Department of Medicine, Misasa Medical Center, Okayama University Medical School, Tottori, Japan
  • ASHIDA Kozo
    Department of Medicine, Misasa Medical Center, Okayama University Medical School, Tottori, Japan
  • MITSUNOBU Fumihiro
    Department of Medicine, Misasa Medical Center, Okayama University Medical School, Tottori, Japan
  • HOSAKI Yasuhiro
    Department of Medicine, Misasa Medical Center, Okayama University Medical School, Tottori, Japan
  • TSUGENO Hirofumi
    Department of Medicine, Misasa Medical Center, Okayama University Medical School, Tottori, Japan
  • NISHIDA Norikazu
    Department of Medicine, Misasa Medical Center, Okayama University Medical School, Tottori, Japan
  • NAGATA Takuya
    Department of Medicine, Misasa Medical Center, Okayama University Medical School, Tottori, Japan
  • YOKOI Tadashi
    Department of Medicine, Misasa Medical Center, Okayama University Medical School, Tottori, Japan
  • TAKATA Shingo
    Department of Medicine, Misasa Medical Center, Okayama University Medical School, Tottori, Japan
  • TANIZAKI Yoshiro
    Department of Medicine, Misasa Medical Center, Okayama University Medical School, Tottori, Japan

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  • 気管支喘息に対する温泉療法とエゴマ油食の効果

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Abstract

N-3 fatty acids are reportedly effective for asthma. In addition, spa therapy has been reported to be effective for patients with asthma. In the present study, the effects of spa therapy combined with perilla seed oil-rich diet (rich in n-3 fatty acid) were examined on asthma. A total of 14 asthmatic patients had a complex spa therapy and consumed a perilla seed oil-rich diet-rich in α-linolenic acid (α-LNA) for 8 weeks. Generation of leukotriene (LT) C4 by leucocytes, respiratory function were analyzed. The generation of LTC4 by leucocytes decreased significantly for 2, 4 and 8 weeks (P<0.05). Peak expiratory flow (PEF) values increased significantly for 2, 4, 6 and 8 weeks (P<0.05). The values of ventilatory parameters [forced vital capacity (FVC), forced expiratory volume in one second (FEV1), forced expiratory flow after 25% of expired FVC (FEF25), forced expiratory flow after 75% of expired FVC (FEF75), mean expiratory flow during the middle half of the FVC (FEF25-75)] revealed a significant increase after 4 and 8 weeks of the modified diet (P<0.05). The results suggest that spa therapy combined with a perilla seed oil-rich diet are effective in the treatment of asthma in terms of its ability to suppress LTC4 generation by leucocytes, and in inducing an improvement of pulmonary function.

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