Long-term Spa Therapy Prevents the Progressive Pathological Changes of the lung in Patients with Pulmonary Emphysema.

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  • MITSUNOBU Fumihiro
    Department of Midicine, Misasa Medical Center, Okayama University Medical School
  • HOSAKI Yasuhiro
    Department of Midicine, Misasa Medical Center, Okayama University Medical School
  • ASHIDA Kozo
    Department of Midicine, Misasa Medical Center, Okayama University Medical School
  • TSUGENO Hiroshi
    Department of Midicine, Misasa Medical Center, Okayama University Medical School
  • OKAMOTO Makoto
    Department of Midicine, Misasa Medical Center, Okayama University Medical School
  • NISHIDA Norikazu
    Department of Midicine, Misasa Medical Center, Okayama University Medical School
  • NAGATA Takuya
    Department of Midicine, Misasa Medical Center, Okayama University Medical School
  • TAKATA Shingo
    Department of Midicine, Misasa Medical Center, Okayama University Medical School
  • YOKOI Tadashi
    Department of Midicine, Misasa Medical Center, Okayama University Medical School
  • TANIZAKI Yoshiro
    Department of Midicine, Misasa Medical Center, Okayama University Medical School

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  • 長期的な温泉療法は肺気腫患者における肺の病理的変化の進行を抑制する

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Abstract

Clinical effects of spa therapy for patients with pulmonary emphysema (PE) were evaluated by observing changes in %LAA of the lung on HRCT, %RV, %FVC, %FEV 1.0, and %DLco values after the long-term therapy. The subjects in this study 16 patients with PE. The subjects were divided into two groups according to the extent of %LAA<-950 HU of the lung on HRCT: %LAA<50% (N=6) and 50%≤%LAA (N=8). 1. Spa therapy significantly improved %LAA (42.5% at the initial stage to 36.3% 24 months after spa therapy), %RV (202.1% to 156.1%) and %DLco 71.0% to 85.7%), but not %FVC and %FEV 1.0, in patients with PE of %LAA<50%, however, significant. Improvement of these parameters was not observed in patients without spa therapy. 2. Spa therapy did not improve the values of %LAA, %RV, and %DLco, as well as %FVC and %FEV 1.0, in patients with PE of 50%≤%LAA. These parameters tended to decrease in the patients of 50%≤%LAA. These results suggest that spa therapy improves %LAA and parameters related to pulmonary function when they are at early stage of PE, however, the therapy was not remarkably effective for these parameters when they were at advanced stage of PE.

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