Relationship between Sleep and Lipid Metabolism

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  • MIYATA Seiko
    Department of Clinical Psychiatry, Nagoya University Graduate School of Medicine
  • NODA Akiko
    Department of Biomedical Sciences, Chubu University Graduate School of Life and Health Sciences
  • IWAMOTO Kunihiro
    Department of Developmental and Geriatric Psychiatry, Nagoya University Graduate School of Medicine
  • OZAKI Norio
    Department of Developmental and Geriatric Psychiatry, Nagoya University Graduate School of Medicine

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  • 睡眠と脂質代謝との関連
  • スイミン ト シシツ タイシャ ト ノ カンレン

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Abstract

<p>Sleep plays an important role in metabolic regulation and insomnia disorder, short sleep and long sleep are also related with dyslipidemia. Among them especially, numerous evidence suggests that sleep disordered breathing is closely associated with dyslipidemia, hypertension and diabetes, and increases the risk of cardiovascular disease. In addition, in recent years, studies that elucidate the molecular mechanism of dyslipidemia due to sleep disorder by a mass spectrometer is increasing. The relationship between severity and lipid species profile in patients with obstructive sleep apnea has been reported, and the previous study revealed a significant overall shift in lipid metabolism, with higher levels of phospholipids under sleep-restricted conditions. Comprehensive analysis of lipid metabolites using a mass spectrometry further the understanding of sleep/wake regulation and the associated metabolic processes, and will be vital to identify robust biomarkers for disease states and drug efficacy. In this paper, we review epidemiological and mass spectrometric studies on the relationship between sleep and dyslipidemia.</p>

Journal

  • Oleoscience

    Oleoscience 19 (7), 285-290, 2019

    Japan Oil Chemists' Society

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