Artificial cell membrane sensor based on nano- and microfabrication techniques

DOI Web Site 13 References
  • HIRANO-IWATA Ayumi
    Graduate School of Biomedical Engineering, Tohoku University
  • OSHIMA Azusa
    Graduate School of Biomedical Engineering, Tohoku University
  • KIMURA Yasuo
    Laboratory for Nanoelectronics and Spintronics, Research Institute of Electrical Communication, Tohoku University
  • NIWANO Michio
    Graduate School of Biomedical Engineering, Tohoku University Laboratory for Nanoelectronics and Spintronics, Research Institute of Electrical Communication, Tohoku University

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Other Title
  • ナノ・マイクロ加工に基づく人工細胞膜センサの研究
  • ナノ ・ マイクロ カコウ ニ モトズク ジンコウ サイボウマク センサ ノ ケンキュウ

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Abstract

<p>In this review, we discuss our recent approaches to improving the stability of bilayer lipid membranes (BLMs) based on nano- and microfabrication techniquies. BLMs were prepared across microapertures in silicon (Si) chips or nanoporous alumina films, and their mechanical stability was investigated. BLMs spanning over the porous alumina films showed a low background noise suitable for single-channel recordings, although further improvement in membrane stability was required. BLMs suspended in Si chips showed improved stability, showing a lifetime of 15-45 h and resistance to high voltage and repetitive solution exchanges. The electric properties of these BLMs were improved by coating the BLMs with insulator layers. The next step is the incorporation of biological channels into these BLMs. The realization of channel-incorporated BLMs with mechanical stability is expected to result in various applications including sophisticated biosensors and high-throughput drug screening systems.</p>

Journal

  • Oyo Buturi

    Oyo Buturi 81 (2), 143-146, 2012-02-10

    The Japan Society of Applied Physics

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