Changes in the Oral Treatment of Psoriasis at Fukuoka University

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  • 福岡大学病院皮膚科における乾癬の内服治療の推移
  • 統計 福岡大学病院皮膚科における乾癬の内服治療の推移
  • トウケイ フクオカ ダイガク ビョウイン ヒフカ ニ オケル カンセン ノ ナイフク チリョウ ノ スイイ

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<p>Biologic treatment has dramatically changed the systemic treatment against psoriasis ; however, the transition of oral drugs has not been studied in this biologic era. To elucidate the real-life data of oral systemic treatment of psoriasis in this era, patients who visited our department during the period from January 1, 2010 to March 31, 2016, who were diagnosed as having psoriasis, and who were treated with prescription of cyclosporin, etretinate, or methotrexate were enrolled in this retrospective observational study. The following seven parameters were analyzed : gender, age, type of medicine, duration of treatment, transition to other drugs, combined use of drugs, and presence or absence of transition to molecular targeted drugs. One hundred forty-nine patients were identified. Cyclosporin was the most commonly used medicine (109 cases) in both monotherapy (80 cases) and combination with other systemic drugs. 40.0% of those treated with cyclosporin were shifted to biologics, while the remaining patients were on the same treatment regimen over the long term ; some cases were on cyclosporin for more than 2000 days. Etetinate was administered in 44 cases ; etretinate was administered to mostly elderly patients, and a few patients of reproductive age. The median duration of etretinate use was 255 days, suggesting that it is often used temporarily. Methotrexate was prescribed to 30 patients, and 54.5% of them were switched to biologics, which was the highest rate among the three drugs analyzed. Methotrexate is often used in patients with psoriatic arthritis. In addition, the use of methotrexate.</p>

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