8.2.1　Generation of Reactive Oxygen Species in Aqueous Phase by Carbon-Ion Beam

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  • Matsumoto Ken-ichiro
    Quantitative RedOx Sensing Team (QRST), Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
  • Nyui Minako
    Quantitative RedOx Sensing Team (QRST), Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
  • Ueno Megumi
    Quantitative RedOx Sensing Team (QRST), Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
  • Ogawa Yukihiro
    Quantitative RedOx Sensing Team (QRST), Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
  • Nakanishi Ikuo
    Quantitative RedOx Sensing Team (QRST), Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology

Bibliographic Information

Other Title
  • 8.2.1　炭素イオン線による水相における活性酸素種の生成
  • 炭素イオン線による水相における活性酸素種の生成
  • タンソ イオンセン ニ ヨル スイソウ ニ オケル カッセイ サンソシュ ノ セイセイ

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Abstract

<p>Hydroxyl radical (·OH) generation, hydrogen peroxide (H2O2) generation, and the total amount of oxidation reactions caused by X-ray or carbon-ion beam irradiation to aqueous samples were measured by electron paramagnetic resonance-based methods. The ·OH generation was expected to be localized on the track/range of the carbon-ion beam/X-ray, and millimolar- and molar-levels of ·OH generation were expected. The millimolar-level ·OH generation, H2O2 generation, and total oxidation reaction were suppressed with increasing linear energy transfer (LET). The generation of reactive oxygen species (ROS) was not uniform at the molecular level and was LET dependent. It can be expected that differences in ROS generation and the molecular distribution could make a difference in the quality of radiation therapy.</p>

Journal

  • RADIOISOTOPES

    RADIOISOTOPES 68 (10), 681-691, 2019-10-15

    Japan Radioisotope Association

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