Anti-DNA antibody detected by Farr assay in six patients with rheumatoid arthritis

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  • Farr法で抗DNA抗体が検出された関節リウマチ患者６例の検討

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Abstract

<p>  Patients with rheumatoid arthritis（RA）rarely have anti-dsDNA antibody. We report six patients with RA who had anti-dsDNA antibodies by Farr assay. Systemic lupus erythematosus（SLE）with pleuritis occurred in a patient with Sjögren’s syndrome accompanied with RA who had become anti-dsDNA antibody positive. The other five were treated with anti-TNF drugs and the disease activity of their RA and the anti-dsDNA antibody titers showed a similar trend. Pleuritis occurred in two out of the five patients and they were diagnosed with SLE. The isotype of the anti-dsDNA antibody determined by enzyme immunoassay differed between patients with and without SLE; while a patient whose isotype was IgM did not show any signs or symptoms of lupus, SLE with pleuritis developed in patients who had IgG-isotype anti-dsDNA antibody. It is important to determine the isotype of the autoantibody if patients with RA have anti-dsDNA antibody because their clinical course should depend on the isotype of the anti-dsDNA antibody.</p>

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