Elevated maternal retinoic acid-related orphan receptor-γt enhances the effect of polyinosinic-polycytidylic acid in inducing fetal loss

  • Tome Saki
    Department of Anatomy and Neuroscience, Faculty of Medicine, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8577, Japan Department of Kansei, Behavioral, and Brain Science, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8577, Japan
  • Sasaki Tetsuya
    Department of Anatomy and Neuroscience, Faculty of Medicine, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8577, Japan Department of Kansei, Behavioral, and Brain Science, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8577, Japan
  • Takahashi Satoru
    Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8575, Japan
  • Takei Yosuke
    Department of Anatomy and Neuroscience, Faculty of Medicine, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8577, Japan Department of Kansei, Behavioral, and Brain Science, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8577, Japan

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Abstract

<p>T helper 17 (Th17) cells have been suggested to play a crucial role in various complications during pregnancy by participating in maternal immune activation (MIA). To test a possible role for Th17 cells in MIA-mediated abortion, we analyzed transgenic mice overexpressing retinoic acid receptor-related orphan receptor gamma-t (RORγt), a master regulator of IL-17 producing cell development. These mutant mice (RORγt Tg mice) exhibited a constitutive upregulation of serum IL-17A and decreased E-cadherin expression in cell–cell junctions of placental tissues. Abortion after the administration of a viral-mimicking synthetic double-stranded RNA polyinosinic–polycytidylic acid was more frequent in RORγt Tg mice than wild-type mice. These results suggest that excessive Th17 cell activity alters immune responsiveness and increases the rate of abortion during gestation.</p>

Journal

  • Experimental Animals

    Experimental Animals 68 (4), 491-497, 2019

    Japanese Association for Laboratory Animal Science

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