Elevated maternal retinoic acid-related orphan receptor-γt enhances the effect of polyinosinic-polycytidylic acid in inducing fetal loss
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- Tome Saki
- Department of Anatomy and Neuroscience, Faculty of Medicine, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8577, Japan Department of Kansei, Behavioral, and Brain Science, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8577, Japan
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- Sasaki Tetsuya
- Department of Anatomy and Neuroscience, Faculty of Medicine, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8577, Japan Department of Kansei, Behavioral, and Brain Science, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8577, Japan
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- Takahashi Satoru
- Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8575, Japan
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- Takei Yosuke
- Department of Anatomy and Neuroscience, Faculty of Medicine, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8577, Japan Department of Kansei, Behavioral, and Brain Science, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8577, Japan
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説明
<p>T helper 17 (Th17) cells have been suggested to play a crucial role in various complications during pregnancy by participating in maternal immune activation (MIA). To test a possible role for Th17 cells in MIA-mediated abortion, we analyzed transgenic mice overexpressing retinoic acid receptor-related orphan receptor gamma-t (RORγt), a master regulator of IL-17 producing cell development. These mutant mice (RORγt Tg mice) exhibited a constitutive upregulation of serum IL-17A and decreased E-cadherin expression in cell–cell junctions of placental tissues. Abortion after the administration of a viral-mimicking synthetic double-stranded RNA polyinosinic–polycytidylic acid was more frequent in RORγt Tg mice than wild-type mice. These results suggest that excessive Th17 cell activity alters immune responsiveness and increases the rate of abortion during gestation.</p>
収録刊行物
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- Experimental Animals
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Experimental Animals 68 (4), 491-497, 2019
公益社団法人 日本実験動物学会
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詳細情報 詳細情報について
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- CRID
- 1390001277381844992
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- NII論文ID
- 130007742227
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- NII書誌ID
- AA11032321
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- ISSN
- 18817122
- 00075124
- 13411357
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- NDL書誌ID
- 030067288
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- PubMed
- 31178537
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可