Body iron accumulation in obesity, diabetes and its complications, and the possibility of therapeutic application by iron regulation

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  • Horinouchi Yuya
    Department of Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Ikeda Yasumasa
    Department of Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Tamaki Toshiaki
    Department of Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School

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  • 肥満・糖尿病とその合併症における生体内鉄蓄積と鉄制限による治療応用への可能性
  • ヒマン ・ トウニョウビョウ ト ソノ ガッペイショウ ニ オケル セイタイナイテツ チクセキ ト テツ セイゲン ニ ヨル チリョウ オウヨウ エ ノ カノウセイ

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Abstract

<p>Iron is an essential trace metal element for maintaining vital functions, and it is involved in hemoglobin synthesis, redox reaction, enzyme activity, cell proliferation and apoptosis in various cells. Iron deficient-related diseases represented anemia are well-known, on the other hand, iron overload disease has attracted little attention. Excessive iron produces hydroxyl radicals via Fenton/Haber-Weiss reaction, causing organ damage in hereditary iron overload diseases. Additionally, it has been clarified that iron accumulation is involved in the pathological conditions even in metabolic diseases thought to be unrelated to iron so far. Therefore, the role of iron in the living body has been raised attention again. Recent studies have reported that body iron content is associated with both obesity and diabetes, and iron might be an aggravating factor of obesity and diabetes. We have revealed that iron chelating agent reduced oxidative stress and inflammation, suppressing the development of adipose hypertrophy in KKAy mice. Dietary iron restriction also diminishes oxidative stress, leading to the inhibition of increased albuminuria excretion and glomerular lesions in db/db mice. In this review, we give an outline of the role of iron on obese and diabetes, and diabetic kidney disease, and present the possibility of application to treatment with iron regulation in those disorders.</p>

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