Total Synthesis of Nuphar Thioalkaloid and Their Hidden Electrophilicity

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  • Kohyama Aki
    Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama

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  • 二量体チオアルカロイドの全合成とファーマコフォアに隠された求電子構造

Abstract

<p>Nuphar alkaloids are a small family of bioactive terpene alkaloids with unusual bis(spirothiolane)structure. This review focused on dimeric Nuphar thioalkaloids containing hemiaminal moieties. Total syntheses of these alkaloids by Wu and Zakarian and bioorganic study by Shenvi are described.</p>

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