Two-year outcomes of anticoagulation for acute ischemic stroke with nonvalvular atrial fibrillation—SAMURAI-NVAF Study
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- Yoshimura Sohei
- Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center
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- Koga Masatoshi
- Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center
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- Sato Shoichiro
- Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center
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- Todo Kenichi
- Department of Neurology, Kobe City Medical Center General Hospital
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- Yamagami Hiroshi
- Department of Neurology, National Cerebral and Cardiovascular Center
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- Kumamoto Masaya
- Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center
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- Itabashi Ryo
- Department of Stroke Neurology, Kohnan Hospital
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- Terasaki Tadashi
- Department of Neurology, Japanese Red Cross Kumamoto Hospital
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- Kimura Kazumi
- Department of Neurological Science, Graduate School of Medicine, Nippon Medical School Hospital
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- Yagita Yoshiki
- Department of Stroke Medicine, Kawasaki Medical School
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- Shiokawa Yoshiaki
- Departments of Neurosurgery and Stroke Center, Kyorin University School of Medicine
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- Kamiyama Kenji
- Department of Neurosurgery, Nakamura Memorial Hospital
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- Okuda Satoshi
- Department of Neurology, NHO Nagoya Medical Center
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- Okada Yasushi
- Department of Neurology and Cerebrovascular Medicine, NHO Kyushu Medical Center
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- Takizawa Shunya
- Department of Neurology, Tokai University School of Medicine
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- Hasegawa Yasuhiro
- Department of Neurology, St. Marianna University School of Medicine
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- Kameda Tomoaki
- Division of Neurology, Jichi Medical University School of Medicine
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- Shibuya Satoshi
- Department of Neurology, South Miyagi Medical Center
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- Nagakane Yoshinari
- Department of Neurology, Kyoto Second Red Cross Hospital
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- Ito Yasuhiro
- Department of Neurology, TOYOTA Memorial Hospital
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- Matsuoka Hideki
- Department of Cerebrovascular Medicine, NHO Kagoshima Medical Center
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- Takamatsu Kazuhiro
- Department of Neurology, Ohta Memorial Hospital
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- Nishiyama Kazutoshi
- Department of Neurology, Kitasato University School of Medicine
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- Fujita Kyohei
- Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center
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- Kamimura Teppei
- Department of Neurology, National Cerebral and Cardiovascular Center
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- Ando Daisuke
- Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center
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- Ide Toshihiro
- Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center
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- Yoshimoto Takeshi
- Department of Neurology, National Cerebral and Cardiovascular Center
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- Shiozawa Masayuki
- Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center
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- Matsubara Soichiro
- Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center
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- Yamaguchi Yoshitaka
- Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center
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- Kinoshita Naoto
- Department of Neurology, National Cerebral and Cardiovascular Center
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- Matsuki Takayuki
- Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center
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- Takasugi Junji
- Department of Neurology, National Cerebral and Cardiovascular Center
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- Tokunaga Keisuke
- Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center
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- Higashida Kyoko
- Department of Neurology, National Cerebral and Cardiovascular Center
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- Homma Kazunari
- Department of Neurology, Tokai University School of Medicine
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- Kario Kazuomi
- Division of Neurology, Jichi Medical University School of Medicine
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- Arihiro Shoji
- Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center
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- Toyoda Kazunori
- Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center
書誌事項
- タイトル別名
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- Two-Year Outcomes of Anticoagulation for Acute Ischemic Stroke With Nonvalvular Atrial Fibrillation ― SAMURAI-NVAF Study ―
この論文をさがす
説明
<p>Background:We determined the 2-year long-term risk-benefit profile in patients with stroke or transient ischemic attack (TIA) receiving warfarin or direct oral anticoagulants (DOACs) for nonvalvular atrial fibrillation (NVAF) using a prospective, multicenter, observational registry in Japan.</p><p>Methods and Results:NVAF patients within 7 days after onset of ischemic stroke/TIA were enrolled in 18 stroke centers. Outcome measures included ischemic and bleeding events and death in the 2-year follow-up period. We enrolled 1,116 patients taking either warfarin (650 patients) or DOACs (466 patients) at acute hospital discharge. DOAC users were younger and had lower National Institutes of Health Stroke Scale, CHADS2and discharge modified Rankin Scale scores than warfarin users (P<0.0001 each). Incidences of stroke/systemic embolism (adjusted hazard ratio, 1.07; 95% CI, 0.66–1.72), all ischemic events (1.13; 0.72–1.75), and ischemic stroke/TIA (1.58; 0.95–2.62) were similar between groups. Risks of intracranial hemorrhage (0.32; 0.09–0.97) and death (0.41; 0.26–0.63) were significantly lower for DOAC users. Infection was the leading cause of death, accounting for 40% of deaths among warfarin users.</p><p>Conclusions:Stroke/TIA patients receiving DOACs for secondary prevention were younger and had lower stroke severity and risk indices than those receiving warfarin. Estimated cumulative incidences of stroke and systemic embolism within 2 years were similar between warfarin and DOACs users, but those of death and intracranial hemorrhage were significantly lower among DOAC users.</p>
収録刊行物
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- Circulation Journal
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Circulation Journal 82 (7), 1935-1942, 2018-06-25
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001288039161344
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- NII論文ID
- 130007410633
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL書誌ID
- 029056702
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- PubMed
- 29863095
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- NDLサーチ
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- PubMed
- CiNii Articles
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