A child with Henoch-Schönlein purpura successfully treated with diaphenyl sulfone

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  • ジアミノジフェニルスルホンが奏功した小児のIgA血管炎の1例
  • ジアミノジフェニルスルホン ガ ソウコウ シタ ショウニ ノ IgA ケッカンエン ノ 1レイ

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Abstract

An 8-year-old boy presented with bilateral lower extremity purpura, pain in the bilateral wrists, left ankle, and bilateral knees, and fever. Redness of the pharynx and tonsils and palpable purpura involving the entire bilateral lower extremities were observed at initial consultation; skin biopsy was performed on the lower extremity purpura. Based on pathological findings of leukocytoclastic vasculitis, the child was diagnosed with Henoch-Schönlein purpura. Although treatment was initiated with oral vitamin C, tranexamic acid, and acetaminophen, with topical application of steroid, arthralgia persisted and new eruptions developed. Diaphenyl sulfone (DDS) was administered at 1 mg/kg per day, and the symptoms rapidly improved. DDS was gradually tapered and oral administration of DDS ended approximately 6 months after initial use. The patient has had no recurrence for one year following completion of treatment.

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