Dissociation of eGFR from creatinine (eGFRcre) and eGFR from cystatine C (eGFRcys) in clinical practice

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  • 臨床現場におけるクレアチニンとシスタチンCから算出した推算GFRの乖離

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<p>Glomerular filtration rate (eGFR) estimated from creatinine (eGFRcre) and eGFR estimated from cystatine C (eGFRcys) were presented in 2008 and 2012, respectively. Even though eGFR is frequently used to estimate renal function in clinical practice, we often encounter some cases in which the eGFRcre is very different from eGFRcys. Therefore, we investigated the consistent probability between eGFRcre and eGFRcys or the features of the above cases in this study. Results showed that the correlative relationship was y = 0.92x + 2.44 and the coefficient of correlation was r = 0.868. On the other hand, the consistent probability of clinical stratification in chronic kidney disease determined on the basis of eGFRcre and eGFRcys was 55.8%. In inconsistent cases, the number of cases in which the severity determined from eGFRcre was higher than that determined from eGFRcys was the same as that of cases in which the severity determined from eGFRcre was lower than that determined from eGFRcys. Furthermore, cases diagnosed as different at two stages accounted for 3.5% (8 cases). The eGFRcys/eGFRcre ratio tended to be higher in young patients and lower in old patients than in those in their 60s (close to 1). The eGFRcys/eGFRcre ratio also tended to increase with increasing area of body surface and serum albumin level, but it is low in those with serious proteinuria. In conclusion, it is important to use the two estimation parameters while understanding their features and factors of dissociation when estimating renal function.</p>

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