Early induction of plasma exchange and immunosuppression therapy was effective in a child with anti-muscle-specific kinase positive myasthenia gravis : a case report

DOI
  • Asai Hiroshi
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka
  • Ishii Masahiro
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka
  • Shimono Masayuki
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka
  • Igarashi Ryota
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka
  • Matsuda Yumeko
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka
  • Fukuda Tomofumi
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka
  • Senju Ayako
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka
  • Takano Shiho
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka
  • Shiota Naoki
    UBE Industries, LTD. Department of Health Care & Support Center, Environment, Ube, Yamaguchi
  • Kusuhara Koichi
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka

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Other Title
  • 早期の単純血漿交換療法と免疫抑制剤導入が有効であった抗筋特異的チロシンキナーゼ (MuSK) 抗体陽性重症筋無力症の1例

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<p>  We report the case of a 12 year-old girl with anti-muscle-specific kinase (MuSK) positive myasthenia gravis (MG). She exhibited ptosis, dysphagia, and facial muscle weakness and was tested positive for MuSK autoantibodies. She was initially treated with methylprednisolone pulse therapy ; however, her symptoms persisted. She then underwent five sessions of plasma exchange, which was very effective. Subsequently, she was prescribed oral tacrolimus and has maintained complete stable remission for 2 years. Aggressive treatments including the early induction of plasma exchange and immunosuppression therapy may be effective for childhood-onset anti-MuSK positive MG.</p>

Journal

  • NO TO HATTATSU

    NO TO HATTATSU 50 (4), 288-291, 2018

    The Japanese Society of Child Neurology

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