Comparison of Detectors and Cell Configurations in Flow-Injection Potentiometeric Technique of Pharmaceutical Analysis

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Abstract

Carbon paste and PVC electrodes were constructed and incorporated in the flow injection system for potentiometric determination of amantadine (AM), metformin (MF), ranitidine (RN) and trimetazidine (TRMZ). Wall-jet and continuous flow cells were designed where the wall-jet cell showed better performance regarding the sample dispersion and sensitivity to the change in flow rate. CPEs were more suitable for incorporation in the flow-injection systems due to its fast response, mechanical strength and lifetime. The proposed electrodes showed linear calibration graphs in the concentration range from 10-5 to 10-1 mol L-1 with Nernstian slopes values of 61.4±1.7, 60.1±0.99, 65.5±2.0 and 30.9±1.1 mV decade-1 for AM, MF, RN and TRMZ, respectively. The developed electrodes have been successfully applied for flow injection potentiometric determination of the investigated drugs in their pharmaceutical formulation with sample output of 120 samples h-1 and the advantage of simplicity, accuracy and automation feasibility.

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